The ability to implement effective autonomous hypersonic strikes against an adversary can potentially change the balance of power for our forces located in proximity to a powerful adversary, significantly extending the depth of our defense. Hypersonic weapons have an advantage over slower missiles in that they both reduce the response time of a strike and are more difficult to intercept. The fastest response time for weapons deployed at large distances from the theater of operations would be achieved by boost-glide hypersonic strike weapons (HSW) or maneuverable ballistic re-entry vehicles (MBRV) launched on a depressed trajectory. Both approaches could be made more economical by launching multiple HSW or MBRV from a single rocket, similar to our approach with our nuclear deterrent. Hypersonic cruise missiles launched from strategic bombers would have slower response times, but may be more economical.